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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPP2 All Species: 26.97
Human Site: S936 Identified Species: 45.64
UniProt: P29144 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29144 NP_003282.2 1249 138350 S936 A L L G K K K S S N L T L P P
Chimpanzee Pan troglodytes XP_001151602 1249 138350 S936 A L L G K K K S S N L T L P P
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q64514 1262 139860 S936 A L L G K K K S S S L T L P P
Rat Rattus norvegicus Q64560 1249 138274 S936 A L L G K K K S S S L T L P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513544 1367 152093 S1041 A L L G K K K S N S L T L P P
Chicken Gallus gallus XP_425591 1248 138209 S935 A L L G K K K S N S L T L P P
Frog Xenopus laevis NP_001085380 1261 139671 A937 A L L G K K K A N S Q T L P P
Zebra Danio Brachydanio rerio XP_693179 595 63935 T303 I G D T R L S T M E T G T G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V6K1 1441 158719 Y1051 C I V G G R K Y V S S P L R L
Honey Bee Apis mellifera XP_395521 1450 161968 K944 Q A I I G G K K M I A A S V P
Nematode Worm Caenorhab. elegans Q09541 1374 151070 K992 A T L G K E C K F A G K A L L
Sea Urchin Strong. purpuratus XP_788834 1215 133209 N923 V D V Y Q T V N G A L N G K A
Poplar Tree Populus trichocarpa XP_002318216 1299 143140 F977 P V M G N G A F K S S V L V P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_193817 1380 152349 S1056 T G N G A F K S S V L M P G V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. N.A. N.A. 95.3 96.8 N.A. 81.2 86 80.4 37.7 N.A. 34 41.3 35 54.7
Protein Similarity: 100 99.7 N.A. N.A. N.A. 97.4 98.7 N.A. 86.6 94.6 91.3 43.1 N.A. 53 59.2 53.4 71.6
P-Site Identity: 100 100 N.A. N.A. N.A. 93.3 93.3 N.A. 86.6 86.6 73.3 0 N.A. 20 13.3 26.6 6.6
P-Site Similarity: 100 100 N.A. N.A. N.A. 100 100 N.A. 100 100 93.3 13.3 N.A. 46.6 20 33.3 26.6
Percent
Protein Identity: 38 N.A. N.A. 37.4 N.A. N.A.
Protein Similarity: 56.9 N.A. N.A. 54.1 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 33.3 N.A. N.A.
P-Site Similarity: 40 N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 58 8 0 0 8 0 8 8 0 15 8 8 8 0 8 % A
% Cys: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 8 0 8 8 0 0 0 0 0 0 % F
% Gly: 0 15 0 79 15 15 0 0 8 0 8 8 8 15 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 8 8 0 0 0 0 0 8 0 0 0 0 0 % I
% Lys: 0 0 0 0 58 50 72 15 8 0 0 8 0 8 0 % K
% Leu: 0 50 58 0 0 8 0 0 0 0 58 0 65 8 22 % L
% Met: 0 0 8 0 0 0 0 0 15 0 0 8 0 0 0 % M
% Asn: 0 0 8 0 8 0 0 8 22 15 0 8 0 0 0 % N
% Pro: 8 0 0 0 0 0 0 0 0 0 0 8 8 50 65 % P
% Gln: 8 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 8 8 0 0 0 0 0 0 0 8 0 % R
% Ser: 0 0 0 0 0 0 8 50 36 50 15 0 8 0 0 % S
% Thr: 8 8 0 8 0 8 0 8 0 0 8 50 8 0 0 % T
% Val: 8 8 15 0 0 0 8 0 8 8 0 8 0 15 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _